Modeling Radiotherapy Induced Normal Tissue Complications: An Overview beyond Phenomenological Models

Modeling Radiotherapy Induced Normal Tissue Complications: An Overview beyond Phenomenological Models

An overview of radiotherapy (RT) induced normal tissue complication probability (NTCP) models is presented. NTCP models based on empirical and mechanistic approaches that describe a specific radiation induced late effect proposed over time for conventional RT are reviewed with particular emphasis on their basic assumptions and related mathematical translation and their weak and strong points.

Predicting Normal Tissue Complications In Radiotherapy

.> Introduction Patient-to-patient variations in the radiosensitivity of normal and neoplastic tissues are well known and recognized both in vivo(1.2) and in vitro studies. (3.6) The typical example is the autosomal recessive disease ataxia-telangiectasia (AT). ATM patients are extremely sensitive to ionizing radiation. The patients develop severe to fatal radiation reactions when treated by st...

An overview of Electronic tissue Compensation (ECOMP) for breast Radiotherapy

Treatment of radiation-induced normal tissue lesions

Comparing of different normal tissue complication probability models for plan evaluation of radical radiotherapy for esophageal cancer

Introduction: Chemoradiation is a well-established protocol for management of localized esophageal cancer. However, some early and late toxicities are associated with this therapy. Plan evaluation in term of normal tissue complication probability (NTCP) may help clinicians to tailor this therapy more individually. Given the variety of present radiobiological models, the choice...